USS Mistletoe (1861) was a steamer purchased by the Union Navy during the American Civil War. She was planned by the Union Navy for use as a tugboat whose task it was to tow other ships or to free them when they became stuck or otherwise inoperable. Mistletoe, a small steam tug, was built as Restless at St. Louis, Missouri, in 1861; purchased by the U.S. War Department early in the Civil War for service in the Western Flotilla and renamed; transferred to the Navy at Cairo, Illinois, 30 September 1862; and commissioned 1 October 1862, Acting Ens. James L. Quigley in command.