Santa Fe's maiden deployment was in 1997 to the Persian Gulf and Western Pacific. In 1998, she completed a Selected Rectricted Avialability in Pearl Harbor Naval Shipyard. In 1999, she was again deployed to the Persian Gulf and Western Pacific earning a Meritorious Unit Commendation and Coast Guard Meritorious Unit Commendation. In 2001, she deployed to the Western Pacific and Persian Gulf earning two Meritorius Unit Commendations as well as earning her first coveted CSS-7 Battle E.