In Homestuck there is a connection between genetics and the online handles used by Sburb players. GCAT is a common presentation of the pairings of bases in the double helix structure of DNA, in Homestuck, sixteen abbreviations of online handles can be derived from two-letter combinations of GCAT. Four of them are used by the eight kids (each one used twice), and the other twelve are used by the trolls. The cherubs expand upon the genetic pattern from DNA to include RNA, with Calliope's handle, uranianUmbra (UU) and Caliborn's handle, undyingUmbrage (uu), which use the letter U, corresponding to uracil, which replaces thymine (T) when information is copied from DNA to RNA. A connection can also be made between these two handles and genotypes, where dominant genes are represented by uppercas