Orpheus was a mystical drug that was highly potent and intoxicating. It was used mostly by demons but humans used it as well. In the case of a human, they got high and vampires fed on them to get the same effect. The effect appeared as if the user was high on heroin or another opiate. Too much Orpheus could result in a coma or even death. The drug only caused a high in humans after they were bitten by a vampire, with the subject operating at his or her apparent physical norm until they were bitten by a vampire.