Rose wrote for the likes of Hope and Milton Berle on radio and helped write the all-star 1945 Command Performance parody "Dick Tracy in B Flat" (starring Hope, Frank Sinatra, Dinah Shore, the Andrews Sisters and others). In addition to the Hope movies, Rose wrote (often with partner Melville Shavelson) scripts or dialogue for Always Leave Them Laughing (a Berle vehicle, 1949), assorted Doris Day musical comedies, the Cary Grant romantic comedy Houseboat (1958, netting an Oscar nomination for best screenplay), The Five Pennies (1959, with Danny Kaye), Papa's Delicate Condition (1963), and A Touch of Class (1973, with Glenda Jackson, earning another Oscar nod). The Great Muppet Caper was his final film credit.