The Level 6 Shift attempt on Misaka Mikoto was an attempt to induce a Level 6 Shift on the third-ranked Level 5 esper Misaka Mikoto into a Level 6 by Kihara Gensei. It failed after the destruction of Shokuhou Misaki's Exterior, through the combined efforts of her, Shirai Kuroko, Kamijou Touma, and Sogiita Gunha.