McGuire may best be remembered for her recurring role as Kate Malone on the long-running family sitcom Growing Pains. McGuire's "Sanctuary" co-star Andrew Koenig appeared in McGuire's first episode in his popular role as "Boner". McGuire also had a recurring role on Hill Street Blues (working with Barbara Babcock, Barbara Bosson, and James B. Sikking) in 1982 and the soap opera Falcon Crest (working with Brett Cullen, Bruce Gray, and Robert Ito) during the 1988-89 television season.