In the 1990s, Cascio worked for the futurist and scenario planning firm Global Business Network. In 2003, he co-founded the popular environmental website Worldchanging, where he was a primary contributor. At Worldchanging, he covered a broad variety of topics, from energy and climate change to global development, open source, and bio- and nanotechnologies. In early 2006, he left Worldchanging, and now blogs at Open The Future, a title based on his WorldChanging.com essay, 'The Open Future'.