Ambrosio serves as an ambassador for the National Multiple Sclerosis Society. In 2012, she came in 6th on the Forbes top-earning models list, estimated to have earned $6.6 million in one year. She'll play herself in the 2016 movie, Teenage Mutant Ninja Turtles: Out of the Shadows. The scenes were she and Vern Fenwick (played by Will Arnett) watch a Clippers' game were the first scenes shot for the film.