In 2375, the Borg Collective detected one of Species 6339's last surviving shuttlecraft with thirteen individuals aboard, and a cube was sent to intercept it. However, unknown to the Borg, Species 6339 had introduced a synthetic pathogen made to attack the programs in a Borg cube's vinculum. The virus brought chaos to the Borg's ordered hive consciousness, which led to the destruction of the cube. (VOY: "Infinite Regress")