D'Spayre was encountered at the Nexus of All Realities. He captured young sorceress Jennifer Kale and the spirit of her deceased teacher, Dakimh. He tied them both to an arcane tower on the Nexus, trying to use the evil mystic energies of the tower to corrupt his prisoners so that they would use their magic powers to serve D'Spayre. D'Spayre had killed Dakimh's mentor Zhered-Na centuries ago. D'Spayre has tried to defeat the spirits of Cyclops and of Doctor Strange, but each of them was able to get free of D'Spayre's illusions.