The Investors first appeared working with Monstroso who was in dire need of a new heart. The Investors then took the dying King Gorilla's heart and kidnapped Billy Quizboy who was pretending to be a doctor even though he did not have a degree. They then gave Billy a medical license so he could perform the heart transplant for Monstroso. The group then left after S.P.H.I.N.X. showed up.