The first church at the site dates to the 11th century; while the present building was constructed in the 16th century on designs of the Bolognese Ottaviano Mascherino. The main altarpiece and cupola are painted by Ludovico Rusconi Sassi. In the chapels are works of art by Antoniazzo Romano, Camillo Rusconi, François Duquesnoy, Alessandro Turchi and a Nativity by Pietro da Cortona. The refectory has a series of Mannerist frescoes (1550) by Francesco Salviati (1550), and contains the 15th century tomb of Pope Eugene IV by Isaia of Pisa, transferred here from the Old Saint Peter's Basilica.