Thigpen was born and raised in El Dorado, Arkansas. He played prep school football at Potomac High School in Dumfries, Virginia, where he was honored as a Parade All-American and Virginia Defensive Player of the Year. Thigpen was recruited to play college football at the University of North Carolina for head coach Mack Brown. Thigpen was a three-time All-ACC linebacker for the Tar Heels. He was co-captain of the 1992 team that went 9–3 and were Peach Bowl champions. Upon graduation, Thigpen played professionally for the New York Giants and Barcelona Dragons.