Antonio Manrique de Lara, 2nd Duke of Nájera (died December 13, 1535) was a Spanish noble and military leader, and Viceroy of Navarre between 1516 and 1521. He was the second son of Pedro Manrique de Lara, captain general of Army of Navarre and capitán general de la Frontera de Aragón, Navarra y Jaén. His mother was Guiomar de Castro. His father was named 1st Duke of Nájera by Ferdinand II of Aragon and Isabella I of Castile on August 30, 1482. Antonio became second Duke in 1515, when his father died. He was also 3rd Count of Treviño.