Tireless Run is useful when players have to run for long periods of time, such as during the Summer's End quest, or while doing a special task such as an Agility course or the Pyramid Plunder activity, where players have to do a lot of running in short periods of time. Another location useful for this is the Wilderness. However, familiars are prohibited from entering certain places where unlimited run can be useful (such as the Ape Atoll Agility Course, Dorgesh-Kaan Agility Course or Brimhaven Agility Arena). Some players find Tireless Run useful when Runecrafting, particularly when using the Ourania altar or running Astral runes. However, this cannot be used when runecrafting law runes, because familiars are not allowed on Entrana. Tireless Run is also commonly used for Penguin Hide and S
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