The Metroid Prime Trilogy is about cancer. I often wonder while playing it how much teamwork went on between Retro and Nintendo, because the central theme of the series is virtually unique to Japan: radiation. In fact, I can’t think of any other whole culture in which "radiation" could be considered an honest-to-god theme along the lines of destiny or daddy issues. Some may say that the theme is more broadly about corruption, and that radiation is merely an aspect of this. But it’s pretty hard for me to look at the conflict of the series (outside force falls from above to envelop the world in destruction and lasting radiation that warps everything it touches) as something that isn’t intrinsically about Nagasaki and Hiroshima.