Pandora's Box is an ancient magical box that contains all of the horrifying sorrows of the world and it first appeared in the eponymous episode "Little Box of Horrors" of the Charmed TV series. It is protected by a magical lineage of powerful mortal women called "Guardians" whose sworn duty is to guard it and prevent it from being opened by demons, which is impossible for them to open in the first place, but with enough strategy, they can make the Guardian herself or a mere human open it. That title "Guardian" passes onto the box's next keeper at the death of her current predecessor as the box will move on itself only to it's new Guardian.