Mister Freeze was a renowned scientist whose beloved wife, Nora was diagnosed with a rare illness that would cause her death. As no cure was developed for such illness, Fries used cryogenic technology to freeze Nora's body and preserve it until he found a cure. However, due to a disastrous accident, Freeze was exposed to a series of chemicals that caused his body's homeostasis to change drastically. Freeze's new condition required him to stay at temperatures below zero, turning his skin white.