Huckle and his friends (along with Mac, Bloo, Bill, Aldo, The Powerpuff Girls and their friends) have traveled to London, England and met Pongo, Perdita, and their 15 puppies. They soon learned that the puppies were stolen by Jasper and Horace. They have been hired by the most outrageous Disney villain of all, Cruella De Vil, whom Mojo Jojo, Terrence, and Duchess, work for. Can Huckle, Lowly, Mac, Bloo, Wilt, Eduardo, Coco, Frankie, Mr. Herriman, The Grim Reaper, Wilt, Eduardo, Spreg, Mandy, Mindy, Principal Pixiefrog, Edward, Chip, Skip, Samson, Scoutmaster Lumpus, and Slinkman help Pongo and Perdita get Mac, Bloo,, Coco, Billy, Irwin, Pudin, Adam Lyon, Jake Spidermonkey, Raj, Lazlo, Clam, and the puppies back to London before the villains do any harm on them? You be the judge