Handmade Instrument is a synthesized item in Atelier Rorona: The Alchemist of Arland. Making the Handmade Instrument is required to see Tantris' ending. After getting Tantris' friendship to 80+, you will see an event involving Meredith. After this event, speak to Tantris in the Town Square to get the recipe for the Handmade Instrument. Creating the instrument will unlock the final event for Tantris, allowing his ending to be unlocked.