Piper had ordered Kiwano, an illegal fruit from South America, and got bitten by a sand fly that infected her with Oroya Fever, a rare disease only common in South America. She fell into a coma, but Prue and Phoebe found a spell that would cure the disease. Phoebe took a Ninja Doll and Prue got a vial, allowing them to cast the spell. Piper was awakened, but the doll became alive and infected a nurse, spreading the disease quickly. P3 got closed down for inspection, and the sisters were retained for further observation. Prue astral projected and found a reversal spell. She cast it with Phoebe and Piper falls into a coma again. After an unsuccessful reanimation, Piper's spirit left her body. In the Ghostly Plane, Leo healed her, although the Elders forbade him.