Fra' Claude de la Sengle (1494 – 18 August 1557) was the 48th Grand Master of the Order of Malta, from 1553 his death. His successor was Fra' Jean Parisot de Valette. A native Frenchman, de la Sengle, then Bailli of the French tongue of the Order, was heavily involved in the battles of the Knights against the Turkish corsair and Ottoman admiral Turgut Reis in the Mediterranean and in North Africa, and particularly in the struggles for Djerba and Tripoli.