She performed with Chamki (from India's Sesame co-production, Galli Galli Sim Sim) at the Global Citizen: The World On Stage event at NYU Skirball Center on September 22, 2016 in New York City. Manning's film credits include Crazy/Beautiful, Crossroads, and 8 Mile. She recurred on Hawaii Five-O (as McGarrett's sister Mary Ann) and Sons of Anarchy and guest starred on CSI: Miami, NYPD Blue, and the 2003 revival of The Twilight Zone. Manning is also a fashion designer, forming her own clothing brand in 2005.