Profaci's brother was Salvatore Profaci, who served as his consigliere for years. One of Profaci's brother-in-laws was Joseph Magliocco, who would serve as Profaci's underboss. Profaci's niece Rosalie Profaci was married to Salvatore Bonanno, the son of Bonanno crime family boss Joseph Bonanno. Two of Profaci's daughters married the sons of Detroit Partnership mobsters William Tocco and Joe Zerilli. Profaci was the uncle of the younger Salvatore Profaci and the father of Frank Profaci, both members of the Profaci crime family.