Three years after the GUILT outbreak, many cured GUILT hosts start to show symptoms, and these have some common characteristics, such as toxicosis on the attacked organ. This was named Post-GUILT Syndrome or PGS for short. Over the course of Under the Knife 2, Caduceus USA and Acropolis Pharmaceuticals struggle to try and devise a consistent way of curing PGS. Acropolis develops a serum that can treat GUILT and PGS, though the serum only activates dormant GUILT. It is unknown whether or not Neo-GUILT causes PGS.