Mrs. Buffay is Frank Buffay Sr.'s second wife after he walked out on his first wife Lily and his two twin daughters Ursula and Phoebe. Together she and Frank Sr. have a son, Frank Jr. The first time Phoebe goes to her father's house, she backs out as she's not ready to meet her father. The second time, she ends up hitting Mrs. Buffay's dog Schnoodle when she starts her grandmother's cab so she has to take the dog to the vet for stitches. She visits for a third time and brings Schnoodle back, and she sees Mrs. Buffay and her half-brother Frank Jr. for the first time. When Phoebe asks to see Frank Sr, Mrs. Buffay tells her that Frank went out for groceries 4 years ago and has never returned.