When Dr. Wily's robots are sent out to investigate the crash site of a comet, they inadvertently stumble upon a group of humanoid lion creatures, which proceed to go around turning other humans into lion creatures. When Mega Man enters battle with them, things go from bad-enough-already to even-worse-than-imagined when Dr. Wily makes a truce with Tar, the leader of the Lion Men. Then, after Wily's robots capture Dr. Light and Roll, Tar transforms both Light and Dr. Wily into lion men and uses Wily's own reprogramming ray to reprogram Roll, Proto Man and the Robot Masters. That means Mega Man and Rush are all alone in this battle.