Scream: Gigi's New Killing Spree takes place after Scream: Ghostface's Revenge,Fifi wasn't killed when Natalie shot Mimi in the head, they were able to rush her into surgery and get the bullet out before it was too late,Also her Mimi personalty is gone for good.It also turned out that Jackie Lever wasn't killed she was saved and then given a new identitiy, Det Sam Macher was in a coma, He was devasted to learn what his wife Debbie had gone crazy and killed a few people and also tried to kill Sidney when he woke up.