The Bow of Pestilence is one of the weapons of the Four Horsemen. It is used by Pestilence. The Bow of Pestilence is obtained after completing the quest The First Horseman - Pestilence. It's a unique weapon because it deals disease damage along with regular damage. This makes it a deadly weapon because whenever the enemy is damaged by disease, the opponent's skills are reduced. Recovery takes one minute per level reduced, which can potentially be a long time. Because of this, the only way to avoid the disease damage is to use Protect from Missiles or Deflect Missiles so as to not take damage from the disease. This is because you will not take damage if the arrows do not hit.
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