USS Preston (DD–379) was a Mahan-class destroyer in the United States Navy before and during World War II. She was the fifth Navy ship named for Lieutenant Samuel W. Preston (1840–1865). Preston was laid down 27 October 1934 at the Mare Island Navy Yard, Vallejo, California,and launched 22 April 1936. She was sponsored by Mrs. Edward H. Campbell, commissioned 27 October 1936, with Commander C. D. Swain in command.