Samuel Edwin "Ed" Weir (March 14, 1903 – May 15, 1991) was an American collegiate and professional football player. He was the first Nebraska Cornhusker football player elected to the College Football Hall of Fame and is known as one of Nebraska's greatest athletes. In 2005 the Omaha World-Herald, as part of a series on the 100 Greatest Athletes of Nebraska, named Weir the 19th best athlete in the state's history. Weir played on the line at Nebraska and was captain of the 1923 team that beat the "Four Horsemen" of the University of Notre Dame. He was elected All-American in 1924 and 1925.