Sam The Koopa leaves home because of the strange noise, and sees what going on. He then sees a strange, red and black cloud that rains strange but also evil being known as Infecteriors. They invade Fantendo and, without warning, attacked King Plumber's Castle. Then the Infecterior Mastermind, Textreme, summon a Big Boom to knock him out so it can Infect him. But it is prevented by Pesh, the Pusher's Piles Hero. Pesh suggest him to found Pashie, being held capture by the evil Oldton. The adventure begins.