Mirabile was born on the first day of January 1894 in Alcamo, Sicily to Leo and Josephine "nee Rizzo" Mirabile. In addition to Tony, the Mirabile family would grow to include brothers Vincent, Paul and Joe, as well as a sister Katherine Fundaro who would preceed him in death. Tony arrived in the United States settling in Detroit, Michigan where a contingent of uncles and cousins were engaged in a bloody battle with the Gianolla clan. Tony's level of involvement in the skirmish is unclear but he was visible enough to come into contact with up and coming figures like Joseph Zerilli, William Tocco, Angelo Meli and John Priziola. Tony's stay in Detroit ended when he packed up and moved to Tijuana, Mexico.