In Final Fantasy IV, Final Fantasy V, and Final Fantasy XII, Bio inflicts the ailment status Sap (gradual HP loss), which coexists with the Poison status in both installments, and Bio inflicts its own unique status called the Bio effect in Final Fantasy XI. Bio is usually an advanced Black Magic spell, often obtained midway through the game. In most Final Fantasy titles, Bio heals undead and Poison-based enemies. The spells Bio and Bioga in the Japanese version of Final Fantasy XIII were renamed to be Poison and Poisonga respectively.