The 5th Regiment, Vermont Volunteer Infantry (or 5th VVI) was a three years' infantry regiment in the Union Army during the American Civil War. It served in the Eastern Theater, predominantly in the VI Corps, Army of the Potomac, from September 1861 to June 1865. It was a member of the Vermont Brigade. The regiment lost during service: 201 men killed and mortally wounded, 4 died from accident, 1 executed, 21 died in Confederate prisons and 112 died from disease; total loss: 339. The regiment mustered out of service on June 29, 1865.