It shares an ecological niche with Deviljho, as it is a solitary hunter/ wanderer with no fixed habitat, although it seems to be more common in the Jungle Ruins. It is so powerful and large, that it can prey on even other Snake Wyverns including Basiliskus. It's venomous bite can take down most prey. When enraged, it's Hood will flare up, and it will hiss loudly, and will gain the Dragon element. The Ophiophagus is an agrresive monster when confronted with a fight that it can't get out of, (they prefer to slither away from potential predators/competition) and will fight to the death.