Sopona (or Shapona) is the god of smallpox in the Yoruba religion. The Yoruba people of Nigeria believed that smallpox was a disease foisted upon humans due to Shapona’s “divine displeasure”, and formal worship of the God of Smallpox was highly controlled by specific priests in charge of shrines to the God. People believed that if the priests were angered they were capable of causing smallpox outbreaks through their intimate relationship with Shapona.