The Japanese Vocaloids, including Len Kagamine(Ali Larter), have travelled to America as per usual where they are going to be staying in Los Angeles for this year's summer vacation. While Kaito(Nicholas D'Agosto) hosts a housewarming party in the modern mansion-like house the Vocaloids are staying in, an evil man named Vaster(Simon Pegg) and his supposed henchman Government Man(Nick Frost) finish building the machine that will bring about the end of the world. The machine is soon activated but the world remains unaware of the coming chaos.