Ruy Pérez Ponce de León or Rodrigo Pérez Ponce de León (b. ? - d. 1295) was a Spanish noble of the House of Ponce de León, in the service of the Kingdom of Castile. He was the 15th Grand Master of the Order of Calatrava from 1284 to 1295 under King Sancho IV of Castile and further served as Mayordomo Mayor del Rey from 1293 - 1295, also under Sancho IV.