Calvin Stewart Brice (September 17, 1845 – December 15, 1898) was a Democratic politician from Ohio. Born in Denmark, Morrow County, Ohio, Brice dropped out of Miami University in 1861 to join the Union Army. After a short stint in the Army, he returned to Miami University and earned his undergraduate degree from there in 1863. After the Civil War, Brice studied law at the University of Michigan and then started a business career where he amassed a fortune, largely in railroads. In 1879, he became president of the Lake Erie and Western Railroad and built the Nickel Plate Road in 1882. A Democrat, Brice was the chairman of the Democratic National Committee from 1889 until 1892 and won elected to the Senate in 1890, serving a single term in office.