On a Constitution-class starship, plasma regulators were crucial to the functioning of the warp drive. When the USS Defiant arrived in 2155 of the mirror universe, it was sabotaged by the removal of two of its plasma regulators. (ENT: "In a Mirror, Darkly, Part II") Around stardate 50929.4, Chief Miles O'Brien had to recalibrate a shipment of EPS regulators to prevent them from interfering with Deep Space 9's artificial gravity grid. (DS9: "In the Cards")