The Alpho Galaxy was a stellar region of the galaxy's Alpha or Beta Quadrants. In 2266, The USS Enterprise was exploring the so-called galaxy around stardate 23:009 when it detected the planets Morti and Inicrust on a collision course. They used a particle of the exploded star Doona to prevent the collision, which would have caused harm to the other Alpho planets. (TOS comic: "When Planets Collide")