The show takes place in a small calm town named Single Town. The town seems to be situated in a rocky region since several mountains can be seen in the background. Single Town is two hundred years old and was founded by an alien named Addison Single. The statue in the middle of the town is actually the real Addison Single. Although Single Town looks like an ordinary suburb, it is a meeting place for aliens from different parts of the galaxy. After many episodes, it is revealed that not only aliens want to take over Single Town. Evil human betrayers who have allied themselves with aliens try to help claim Singletown to become the perfect place for aliens. Even in the future and grown up, the team will continute their duties as Monster Buster Club (MBC).