While Yusuke and company were busy with the Saint Beasts, back in Human World, Botan and Keiko had to contend with numerous Possessed Humans. Having no will but their master's, the Possessed attacked Botan and Keiko, although Botan was able to formulate a Bug spray to kill the cause of the Possessed Humans, the Makai insect.They and the rest of the world weren't safe until the Saint Beasts were defeated and the Makai Flute was taken back from Suzaku.