Bryan Grimes (November 2, 1828 – August 14, 1880) was a North Carolina plantation owner and a general officer in the Confederate Army during the American Civil War. He fought in nearly all of the major battles of the Eastern Theater of that war. Grimes was the last man in the Army of Northern Virginia to be appointed by Robert E. Lee as a major general. He also led the final attack of that army shortly before its surrender to Union forces at Appomattox Court House on the morning of April 9, 1865.