In the 22nd century, the Ilari autarch Tieran found a way to transfer his neural pattern from one body to the next, using a cortical implant to enhance the pattern and send it through bioelectric microfibers in his fingers. He lived this way for over two centuries, taking over a succession of bodies until he was finally removed in 2373, via a synaptic stimulator, and destroyed. (VOY: "Warlord") When Tom Paris underwent hyper-evolution after he undertook an experimental warp 10 flight in 2372, The Doctor observed that his synaptic patterns were changing every second. (VOY: "Threshold")