He was born in Gravina in Puglia to Ferdinando III Orsini, duke of Gravina, and Giovanna Frangipani della Tolfa, from Toritto. He was a member of the Orsini of Rome, the third and last member of that family to become Pope. He entered the Dominican Order and received the name Vincenzo Maria. He was named Cardinal-Priest of San Sisto on 22 February 1672 (allegedly, against his will); later he was bishop of Manfredonia, bishop of Cesena and then archbishop of Benevento. In foreign politics, he struggled with John V of Portugal and the Jansenists