The show revolves around freelance quadriplegic John Q. Mind, who performs good deeds throughout small, quirky American towns. In the show's second appearance in American Dad!, John encounters Jimmy Boombox, who accompanies him as his sidekick. At the end of the episode, a stranger claims Mind was once America's greatest soldier, until his legs were blown into his mind. The stranger then vows to find and stop Mind, who is seen still on the run, headed towards the Pentagon.