When the school bus becomes perilously trapped on the edge of a cliff, the driver Ms. Crabtree, searches for help. She finds the highway and hitchhikes a ride from a semi-truck driver, named Mitch, who drives for Red's Roofies. Finding Crabtree attractive, Mitch offers her Red's Roofies. Together they travel around the United States visiting comedy clubs and late night talk shows, as Ms. Crabtree becomes a sensation in stand-up comedy.